Clinicopathological Characteristics of Ten Patients with Atypical Glandular Hyperplasia Transformation of Adenomyosis.

Although adenomyosis is a largely benign disease, malignant transformations do happen in rare cases, resulting in endometrioid adenocarcinoma or sarcoma in the myometrium. Recently, attention has been focused on the malignant transformation of the endometriosis. In 1988, the concept of atypical endometriosis (aEM) was first proposed by LaGrenade and Silverberg,[1] who suggested that aEM might be a precursor of malignant transformations of endometriosis. However, the majority of investigations of aEM focus on endometriosis, while adenomyosis remains understudied. In this article, we report 10 cases of atypical glandular hyperplasia transformation of adenomyosis, of whom the clinical and pathological characteristics are observed.